Akhtar Abbasi J, Funnyé Allen S, Akanno Jonathan
Department of Internal Medicine, King-Drew Medical Center/Charles R. Drew University of Medicine and Science, Los Angeles, CA 90059, USA.
J Natl Med Assoc. 2003 Oct;95(10):986-90.
Our objective is to present a case of symptomatic lead toxicity (plumbism) with abdominal colic and hemolytic anemia following a gunshot wound. It is a retrospective case report and the setting is in a teaching hospital in south central Los Angeles. The case report is that of a patient who presented with abdominal pain, generalized weakness, and hypertension following multiple gunshot wounds, 15 years previously. Other causes of abdominal pain and weakness--such as diabetes mellitus, alcohol abuse, pancreatitis, and substance abuse--were ruled out. Interventions included treatment with the newer oral chelating agent, Succimer (2, 3-dimercaptosuccinic acid), and subsequent surgery. The main outcome was the initial reduction in blood lead levels with improvement of symptoms. Because of a recurrent rise in the blood lead levels, the patient was again treated with Succimer and underwent surgery to remove two bullet fragments from the face. We conclude that lead toxicity should be ruled out in patients presenting with abdominal cramps and a history of a gunshot wound. Prompt therapy--including environmental intervention and chelation therapy--is mandatory, and surgical intervention may be necessary.
我们的目的是报告一例枪伤后出现腹部绞痛和溶血性贫血的症状性铅中毒(铅毒症)病例。这是一篇回顾性病例报告,背景是洛杉矶中南部的一家教学医院。该病例报告的患者15年前因多处枪伤出现腹痛、全身无力和高血压。腹痛和无力的其他原因,如糖尿病、酗酒、胰腺炎和药物滥用,均被排除。干预措施包括使用新型口服螯合剂二巯基丁二酸进行治疗,以及随后的手术。主要结果是血铅水平初步降低,症状改善。由于血铅水平反复升高,患者再次接受二巯基丁二酸治疗,并接受手术从面部取出两枚子弹碎片。我们得出结论,对于有腹部绞痛和枪伤史的患者,应排除铅中毒。必须进行及时治疗,包括环境干预和螯合疗法,可能还需要手术干预。