Messing E M
Division of Urology and Human Oncology, University of Wisconsin, Madison, Wisconsin.
Semin Surg Oncol. 1992 Sep-Oct;8(5):285-92. doi: 10.1002/ssu.2980080507.
Growth factors (GFs) are a class of proteins that bind to specific cell surface receptors (GF-Rs), inducing a variety of responses including mitosis, in susceptible target cells. Abnormal production, expression, and/or function of GFs or GF-Rs can result in unregulated growth, the hallmark of malignant transformation. This chapter reviews those GFs/GF-Rs that have been linked to human bladder cancer. It focuses particularly on one [epidermal growth factor (EGF), which is excreted in urine in high concentrations] and its possible role in the development and growth of urothelial malignancy. Potential clinical applications in diagnosis, staging, prevention, and treatment are discussed.
生长因子（GFs）是一类能与特定细胞表面受体（GF-Rs）结合的蛋白质，可在易感靶细胞中诱导包括有丝分裂在内的多种反应。GFs或GF-Rs的异常产生、表达和/或功能可导致生长失控，这是恶性转化的标志。本章综述了那些与人类膀胱癌相关的GFs/GF-Rs。尤其着重于其中一种[表皮生长因子（EGF），它在尿液中高浓度排泄]及其在上皮恶性肿瘤发生和生长中的可能作用。还讨论了其在诊断、分期、预防和治疗方面的潜在临床应用。
