Kovács I, Novák K, Pomázi L, Hammersberg E
Department of Obstetrics and Gynaecology, Municipal Ujpesti Hospital-Outpatient Clinic, Budapest.
Ther Hung. 1992;40(2):86-9.
The theoretical general principles of triphasic oral contraception are discussed in the introduction. This method, which is the closest to a physiological dosage, seems to be the most advantageous today. International data and the advantages and wide indication field of such "step-up" tablets are also discussed. The observations with the Hungarian Tri-Regol tablet are described in detail. In the course of controlling 355 cycles of 79 women pregnancy was not observed, the tablets were well tolerated by the women-except for some milder side-effects. The use of Tri-Regol needed not be discontinued due to, any unwanted effect or complication. The rate of intermenstrual bleeding was very low, and the triphasic therapy proved to be beneficial in case of manifesting cycle disorders or if the change of the contraceptive tablet became necessary because of intolerance. According to the opinion of the authors the oral contraceptive Tri-Regol is today's drug of choice due to its reliable ovulation inhibitory action, low hormone content, and favourable tolerability.
引言中讨论了三相口服避孕药的理论一般原则。这种方法最接近生理剂量，在当今似乎是最具优势的。还讨论了国际数据以及此类“逐步增加剂量”片剂的优点和广泛适应症范围。详细描述了对匈牙利Tri-Regol片剂的观察结果。在对79名女性的355个周期进行控制的过程中，未观察到怀孕情况，除了一些较轻微的副作用外，女性对这些片剂耐受性良好。使用Tri-Regol无需因任何不良影响或并发症而停药。经间期出血率非常低，并且三相疗法在出现明显的周期紊乱或因不耐受而需要更换避孕药片的情况下被证明是有益的。根据作者的观点，口服避孕药Tri-Regol因其可靠的排卵抑制作用、低激素含量和良好的耐受性，是当今的首选药物。
