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7α-和（25R，S）-26-羟基胆固醇的氘代同位素异构体的合成，用于体内测定胆汁酸两条生物合成途径的内标。

Synthesis of deuterated isotopomers of 7alpha- and (25R,S)-26-hydroxycholesterol, internal standards for in vivo determination of the two biosynthetic pathways of bile acids.

作者信息

Ciuffreda Pierangela, Casati Silvana, Alessandrini Laura, Terraneo Giancarlo, Santaniello Enzo

机构信息

Dipartimento di Scienze Precliniche LITA Vialba, Universitá degli Studi di Milano, Via G.B. Grassi, 74-20157, Milan, Italy.

出版信息

Steroids. 2003 Oct;68(9):733-8. doi: 10.1016/s0039-128x(03)00116-8.

DOI:10.1016/s0039-128x(03)00116-8
PMID:14625005
Abstract

Deuterated isotopomers of 7alpha- and (25R,S)-26-hydroxycholesterol, internal standards for in vivo determination of the two biosynthetic pathways of bile acids formation from cholesterol, were prepared from [2,2,3,4,4,6-2H(6)]-cholesterol and (20S)-[7,7,21,21-2H(4)]-3beta-(tert-butyldimethylsilyl)oxy-20-methylpregna-5-en-21-ol, respectively.

摘要

7α-和(25R,S)-26-羟基胆固醇的氘代同位素异构体分别由[2,2,3,4,4,6-2H(6)]-胆固醇和(20S)-[7,7,21,21-2H(4)]-3β-(叔丁基二甲基甲硅烷基)氧基-20-甲基孕甾-5-烯-21-醇制备而成，它们是用于体内测定胆固醇生成胆汁酸的两条生物合成途径的内标物。

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Synthesis of deuterated isotopomers of 7alpha- and (25R,S)-26-hydroxycholesterol, internal standards for in vivo determination of the two biosynthetic pathways of bile acids.7α-和（25R，S）-26-羟基胆固醇的氘代同位素异构体的合成，用于体内测定胆汁酸两条生物合成途径的内标。
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Biliary bile acids in birds of the Cotingidae family: taurine-conjugated (24R,25R)-3α,7α,24-trihydroxy-5β-cholestan-27-oic acid and two epimers (25R and 25S) of 3α,7α-dihydroxy-5β-cholestan-27-oic acid.鸊鷉科鸟类中的胆汁酸：牛磺酸结合的（24R,25R）-3α,7α,24-三羟基-5β-胆甾烷-27-酸和 3α,7α-二羟基-5β-胆甾烷-27-酸的两个差向异构体（25R 和 25S）。
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