来自非洲的首个完整戊型肝炎病毒（HEV）基因组的系统发育分析。

Phylogenetic analysis of the first complete hepatitis E virus (HEV) genome from Africa.

作者信息

van Cuyck Hélène, Juge François, Roques Pierre

机构信息

Weapons of Mass Destruction Centre (WMD Centre), NATO, AB310, Bd. Leopold III, 1110, Brussels, Belgium.

出版信息

FEMS Immunol Med Microbiol. 2003 Nov 28;39(2):133-9. doi: 10.1016/S0928-8244(03)00241-4.

DOI:10.1016/S0928-8244(03)00241-4

PMID:14625096

Abstract

Hepatitis E virus (HEV) is globally distributed, transmitted enterically and between humans and animals. Phylogenetic analysis has identified five distinct HEV genotypes. The first full-length sequence of an African strain (Chad) is presented and compared to 31 complete HEV genomes available, including the fulminant hepatitis strain from India, swine strains and a strain from Morocco. The two African strains are more closely related to genotype 1 than to any other genotypes and together they possibly form a sub-genotype or sixth genotype. The first evidence for recombination between divergent HEV strains is presented.

摘要

戊型肝炎病毒（HEV）在全球范围内分布，通过肠道传播，可在人和动物之间传播。系统发育分析已确定了五种不同的HEV基因型。本文展示了一株非洲毒株（乍得）的首个全长序列，并将其与31个可用的完整HEV基因组进行比较，其中包括来自印度的暴发性肝炎毒株、猪毒株和来自摩洛哥的一株毒株。这两株非洲毒株与基因型1的关系比与其他任何基因型的关系更为密切，它们可能共同构成一个亚基因型或第六种基因型。本文还展示了不同HEV毒株之间重组的首个证据。