从一名韩国患者中分离鉴定的人戊型肝炎病毒基因 4 型全基因组序列及其分子特征分析。

The complete genome sequence and molecular analysis of human hepatitis E virus genotype IV identified from a Korean patient.

机构信息

Division of Enteric and Hepatitis Viruses, Center for Infectious Diseases, Korea National Institute of Health, Nokbun-dong, Eunpyung-gu, Seoul, Republic of Korea.

出版信息

Arch Virol. 2010 Jun;155(6):1003-8. doi: 10.1007/s00705-010-0661-9.

DOI:10.1007/s00705-010-0661-9

PMID:20390311

Abstract

Hepatitis E virus (HEV) was originally identified as the etiological agent of non-HAV enterically transmitted hepatitis. One HEV strain (FJ763142) was identified from an acute viral hepatitis E patient with IgM anti-HEV in Korea. The complete genome sequence consisted of 7,238 nucleotides (nt) plus a 22-nt poly(A) tail. The strain belongs to genotype IV, with 91% homology compared with AB197674, which was found in a Japanese patient who had traveled to China. This finding suggests that HEV genotype IV already circulates in Korea, and this HEV might be the first example of an indigenous strain.

摘要

戊型肝炎病毒（HEV）最初被确定为非甲型肝炎肠道传播肝炎的病原体。一种 HEV 株（FJ763142）在韩国从一位急性戊型肝炎 IgM 抗-HEV 患者中被鉴定出来。完整基因组序列由 7238 个核苷酸（nt）加上一个 22 个核苷酸的 poly(A)尾组成。该株属于基因型 IV，与在前往中国的日本患者中发现的 AB197674 相比具有 91%的同源性。这一发现表明 HEV 基因型 IV 已经在韩国流行，这种 HEV 可能是首例本土株。