Yao Shu-zhan, Zhang Cheng-qi, Chen Jing, Liu Qing-wei, Li Qing-guo
PET-CT Diagnosis and Treatment Center, Shandong Provincial Hospital, Ji'nan 250021,China.
Di Yi Jun Yi Da Xue Xue Bao. 2003 Nov;23(11):1214-6.
To evaluate the clinical value of (18)F-fluorodeoxyglucose ((18)F-FDG) positron-emission tomography (PET) combined with computer tomography (PET-CT) in the diagnosis and clinical staging of liver cancer.
(18)F-FDG PET-CT was performed preoperatively in 16 cases of primary and 8 metastatic liver cancers. The imaging features of the primary foci were analyzed, followed by measurement of standardized (18)F-FDG uptake. For the metastatic foci, the abnormal metabolism of (18)F-FDG was observed and CT, PET and PET-CT fusion images were obtained for accurate localization of these foci.
(18)F-FDG uptake occurred in the supraclavicular region in 6 (37.5%) of the 16 patients with primary liver cancer, but was detected in the 8 patients with metastatic liver cancer. Fourteen metastatic nodules were found in 5 of the 16 patients with primary liver cancer, located in the lungs (2 cases) or the abdominal cavity (3 cases).
Negative results of (18)F-FDG PET-CT imaging should be carefully evaluated for diagnosing primary liver cancers, considering the very low sensitivity (37.5%) of this imaging modality in this study. But in the cases of metastatic liver cancers this imaging modality may exhibit high sensitivity, and can also be of great value in clinical staging of the primary liver cancers.
评估18F-氟脱氧葡萄糖（18F-FDG）正电子发射断层扫描（PET）联合计算机断层扫描（PET-CT）在肝癌诊断及临床分期中的临床价值。
对16例原发性肝癌及8例转移性肝癌患者术前行18F-FDG PET-CT检查。分析原发性病灶的影像学特征，随后测量标准化18F-FDG摄取情况。对于转移性病灶，观察18F-FDG的代谢异常，并获取CT、PET及PET-CT融合图像以准确定位这些病灶。
16例原发性肝癌患者中，6例（37.5%）在锁骨上区域出现18F-FDG摄取，而8例转移性肝癌患者均检测到该摄取。16例原发性肝癌患者中的5例发现14个转移结节，位于肺部（2例）或腹腔（3例）。
鉴于本研究中该成像方式对原发性肝癌的敏感性极低（37.5%），对于原发性肝癌的诊断，应谨慎评估18F-FDG PET-CT成像的阴性结果。但对于转移性肝癌，该成像方式可能表现出高敏感性，并且在原发性肝癌的临床分期中也具有重要价值。
