口服姬松茸（H1菌株）可抑制肉瘤180接种模型中的肿瘤生长。
Oral administration of Agaricus blazei (H1 strain) inhibited tumor growth in a sarcoma 180 inoculation model.
作者信息
Lee Yun-Lyul, Kim Heui-Jin, Lee Mi-Sook, Kim Ji-Min, Han Jin-Soo, Hong Euk-Ki, Kwon Myung-Sang, Lee Min-Jae
机构信息
Department of Physiology, College of Medicine, Hallym University, Chunchun, Korea.
出版信息
Exp Anim. 2003 Oct;52(5):371-5. doi: 10.1538/expanim.52.371.
Agaricus blazei (H1 strain) was tested for its anticancer activity using a sarcoma 180 (S180) inoculation model and the changing patterns of splenocyte subsets were examined. Its hot-water extract was administered orally to ICR and KSN nude mice that were inoculated with S180. The growth of S180 was significantly inhibited in A.blazei treated groups. Pan T cells significantly increased in all treated groups compared to controls, even in KSN nude mice. Splenocyte subset changes were slightly different between ICR and KSN nude mice. This S180 inoculation model proved to be effective in screening the antitumor effect of basidiomycetes and allowed comparisons of immunological cellular changes between the mouse strains.
利用肉瘤180（S180）接种模型测试了姬松茸（H1菌株）的抗癌活性，并检测了脾细胞亚群的变化模式。将其热水提取物口服给予接种了S180的ICR和KSN裸鼠。在姬松茸处理组中，S180的生长受到显著抑制。与对照组相比，所有处理组中的全T细胞均显著增加，即使在KSN裸鼠中也是如此。ICR和KSN裸鼠之间脾细胞亚群的变化略有不同。该S180接种模型被证明可有效筛选担子菌的抗肿瘤作用，并能比较不同小鼠品系之间的免疫细胞变化。
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