Cobalt-mediated macrocyclizations. Facile synthesis of 2-oxo pyridinophanes via [2 + 2 + 2] cycloaddition of alpha, omega-diynes and isocyanates.
作者信息
Boñaga Llorente V R, Zhang Han-Cheng, Gauthier Diane A, Reddy Indrasena, Maryanoff Bruce E
机构信息
Drug Discovery, Johnson & Johnson Pharmaceutical Research & Development, Spring House, Pennsylvania 19477-0776, USA.
出版信息
Org Lett. 2003 Nov 27;5(24):4537-40. doi: 10.1021/ol030096c.
PMID:14627377
Abstract
[reaction: see text] Cobalt-mediated [2 + 2 + 2] cycloaddition of alpha,omega-diynes and isocyanates provides a direct approach to macrocyclic 2-oxopyridinophanes. This macrocyclization process, which proceeded most efficiently with aliphatic isocyanates, was conveniently performed at a moderate temperature (85 degrees C) without irradiation or syringe-pump addition.
摘要
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