Oppenheimer Jossian, Johnson Whitney L, Figueroa Ruth, Hayashi Ryuji, Hsung Richard P
Division of Pharmaceutical Sciences and Department of Chemistry, University of Wisconsin, Madison, WI 53705 USA.
Tetrahedron. 2009 Jun 27;65(26):5001-5012. doi: 10.1016/j.tet.2009.03.078.
A rhodium(I)-xylyl-BINAP catalyzed asymmetric [2 + 2 + 2] cycloaddition of achiral conjugated aryl ynamides with various diynes is described here. This asymmetric cycloaddition provides a series of structurally interesting chiral N,O-biaryls with excellent enantioselectivity along with a modest diastereoselectivity with respect to both C-C and C-N axial chirality.
本文描述了一种铑（I）-二甲苯基-联萘酚（BINAP）催化的非手性共轭芳基炔酰胺与各种二炔的不对称[2 + 2 + 2]环加成反应。这种不对称环加成反应提供了一系列结构有趣的手性N，O-二芳基化合物，具有优异的对映选择性以及关于C-C和C-N轴手性的适度非对映选择性。
