López A, Vilches J, Alvarez-Ossorio J, Aparicio J, Ronco A, Castiñeiras J
Departamento de Biología Celular y Anatomía Patológica, Universidad de Cádiz.
Actas Urol Esp. 1992 Sep;16(8):620-6.
The microscopic patterns adopted by prostate carcinomas are extraordinarily variable making its histopathological classification and grading extremely complicated. There are numerous systems for prostatic tumours' grading, but many of them lack a truly reproducible character and an acceptable degree of reliability; for this reason, we have studied a series of nuclear microscopic parameters, from a quantitative point of view, in a series of prostatic carcinomas with a minimum follow-up of five years. It was observed that of the morphometric values obtained--area, perimeter, projection on the X- and Y-axis as well as the nuclear roundness factor--the most useful and representative is the latter. Besides, this is an objective parameter to evaluate nuclear anaplasia and can also be considered as a prognostic factor since, in our series, those who died had a greater mean nuclear roundness factor than those who survived.
前列腺癌呈现出的微观模式极其多样，这使得其组织病理学分类和分级极为复杂。前列腺肿瘤的分级系统众多，但其中许多缺乏真正可重复的特性和可接受的可靠程度；因此，我们从定量的角度研究了一系列前列腺癌的一系列核微观参数，这些前列腺癌的随访期最短为五年。据观察，在获得的形态测量值中——面积、周长、在X轴和Y轴上的投影以及核圆度因子——最有用且最具代表性的是后者。此外，这是评估核间变的一个客观参数，并且由于在我们的系列研究中，死亡患者的平均核圆度因子高于存活患者，所以它也可被视为一个预后因素。
