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空肠弯曲菌小肠结肠炎表现为炎症性肠病。

Campylobacter jejuni enterocolitis presenting as inflammatory bowel disease.

作者信息

Quondamcarlo C, Valentini G, Ruggeri M, Forlini G, Fenderico P, Rossi Z

机构信息

Division of Gastroenterology and Hepatology, Regina Apostolorum Hospital, Albano Laziale, Rome, Italy.

出版信息

Tech Coloproctol. 2003 Oct;7(3):173-7. doi: 10.1007/s10151-003-0031-7.

Abstract

We report a case of Campylobacter jejuni enterocolitis presenting as inflammatory bowel disease in a 19-year old woman. After a useless course of corticosteroids, ceftazidime and metronidazole, she was successfully treated with erythromicin. Campylobacter species represent an important cause of gastroenteritis in children and adults. The rate of Campylobacter isolation is 5-6 per 100,000 persons. This rate, however, grossly understimates the actual number of Campylobacter infections. In most cases, Campylobacter enteritis is a self-limiting disease, rarely associated with severe complications. Our case demonstrates the difficulty in distinguishing inflammatory bowel disease (Crohn's disease or ulcerative colitis) at onset from atypical infectious colitis. Unfortunately, corticosteroids (necessary for the treatment of inflammatory bowel disease) may exacerbate infectious etiologies. Campylobacter jejuni should be ruled out when assessing inflammatory bowel diseases at onset (as during flare-ups), especially if corticosteroids or immunosuppressive therapies are required.

摘要

我们报告一例19岁女性空肠弯曲菌小肠结肠炎,其表现为炎症性肠病。在接受了无效的皮质类固醇、头孢他啶和甲硝唑治疗后,她成功地用红霉素治愈。弯曲菌属是儿童和成人胃肠炎的重要病因。弯曲菌的分离率为每10万人中有5至6例。然而,这一比率严重低估了弯曲菌感染的实际数量。在大多数情况下,弯曲菌肠炎是一种自限性疾病,很少伴有严重并发症。我们的病例表明,在发病时将炎症性肠病(克罗恩病或溃疡性结肠炎)与非典型感染性结肠炎区分开来存在困难。不幸的是,(治疗炎症性肠病所必需的)皮质类固醇可能会加重感染病因。在评估炎症性肠病发病时(如在病情发作期间),尤其是在需要使用皮质类固醇或免疫抑制疗法时,应排除空肠弯曲菌感染。

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