四氢异喹啉衍生物与吗啡和氧化震颤素在小鼠体内的抗伤害感受作用之间的相互作用。

The interaction of tetrahydroisoquinoline derivatives with antinociceptive action of morphine and oxotremorine in mice.

作者信息

Vetulani J, Pavone F, Przewłocka B, Borghi V, Nalepa I

机构信息

Department of Biochemistry, Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland.

出版信息

J Neural Transm (Vienna). 2003 Nov;110(11):1205-13. doi: 10.1007/s00702-003-0037-3.

DOI:10.1007/s00702-003-0037-3

PMID:14628186

Abstract

To extend our earlier data on synergistic action of tetrahydroisoquinolines and morphine, we have investigated the analgesic effects of 1,2,3,4-tetrahydroisoquinoline (TIQ) and its 1-methyl-(1-MeTIQ) and N-methyl (N-MeTIQ) analogs on analgesia induced by morphine and oxotremorine. 1-MeTIQ and N-MeTIQ induced a moderate, delayed and prolonged analgesic action measured in the tail-flick test in CD-1 mice; 1-MeTIQ and TIQ prolonged the opiate (morphine, 2.5 mg/kg i.p.) analgesia while TIQ and N-TIQ potentiated cholinergic (oxotremorine, 0.02 mg/kg i.p.) analgesia. The involvement of the opioid and noradrenergic systems in this effect is discussed.

摘要

为了扩展我们早期关于四氢异喹啉与吗啡协同作用的数据，我们研究了1,2,3,4 - 四氢异喹啉（TIQ）及其1 - 甲基 -（1 - MeTIQ）和N - 甲基（N - MeTIQ）类似物对吗啡和氧化震颤素诱导的镇痛作用。在CD - 1小鼠的甩尾试验中，1 - MeTIQ和N - MeTIQ诱导了中度、延迟和延长的镇痛作用；1 - MeTIQ和TIQ延长了阿片类药物（吗啡，2.5mg/kg腹腔注射）的镇痛作用，而TIQ和N - TIQ增强了胆碱能（氧化震颤素，0.02mg/kg腹腔注射）的镇痛作用。本文讨论了阿片类和去甲肾上腺素能系统在这种作用中的参与情况。