Mutoh S, Kobayashi M, Hirata J, Itoh N, Maki M, Komatsu Y, Yoshida A, Sasa H, Kuroda K, Kikuchi Y
Division of Perinatal and Maternal Medicine, Akita University School of Medicine, Japan.
Agents Actions Suppl. 1992;38 ( Pt 2):342-9.
In our previous study 1), 2), 3) we reported the changes of coagulation-fibrinolysis, kallikrein-kinin system and kininase in preclampsis. In this study, we tried to obtain systemic information of chronic DIC status with regard to kallikrein-kinin system in severe preeclampsia. This systemic information was evaluated in 20 cases of normal gravidas from 28 to 42 weeks of gestation as a control by measuring plasma Thrombin/Antithrombin III complex (TAT), tissue plasminogen activator (tPA) plasminogen activator inhibitor (PAI) complex, active plasminogen inhibitor-1 (active PAI), 2PI plasmin complex (PIC).
The levels of plasma TAT and tPA significantly increased (TAT = 10.9 +/- 8.3 ng/ml n = 24 M +/- SD P < 0.02, tPA = 6.1 +/- 3.2 ng/ml n = 10 M +/- SD P < 0.01), tPA PAI C and active PAI markedly increased (tPA PAI C = 85.07 +/- 50.01 ng/ml n = 24 P < 0.05, active PAI = 407.4 +/- 166.0 ng/ml n = 24 P < 0.205), and PIC and D-dimer = 435.1 +/- 145.2 ng/ml n = 8 M +/- SD P < 0.001) in severe preeclampsia as compared with those of normal values (TAT = 6.1 2.0 ng/ml, tPA = 3.6 +/- 1.5 ng/ml, tPA PAI C = 57.9 +/- 30.8 ng/ml, active PAI = 304.2 +/- 148.6 ng/ml, PIC = 0.49 +/- 0.24 mg/ml, D-dimer = 282.9 +/- 75.3 ng/ml).(ABSTRACT TRUNCATED AT 250 WORDS)
在我们之前的研究中，我们报道了子痫前期患者凝血 - 纤溶、激肽释放酶 - 激肽系统及激肽酶的变化。在本研究中，我们试图获取重度子痫前期患者激肽释放酶 - 激肽系统慢性弥散性血管内凝血（DIC）状态的系统信息。通过检测血浆凝血酶/抗凝血酶III复合物（TAT）、组织型纤溶酶原激活物（tPA）、纤溶酶原激活物抑制剂（PAI）复合物、活性纤溶酶原抑制剂 -1（活性PAI）、纤溶酶 -α2纤溶酶抑制物复合物（PIC），对20例妊娠28至42周的正常孕妇作为对照进行了该系统信息评估。
与正常值（TAT = 6.1±2.0 ng/ml，tPA = 3.6±1.5 ng/ml，tPA - PAI - C = 57.9±30.8 ng/ml，活性PAI = 304.2±148.6 ng/ml，PIC = 0.49±0.24 mg/ml，D - 二聚体 = 282.9±75.3 ng/ml）相比，重度子痫前期患者血浆TAT和tPA水平显著升高（TAT = 10.9±8.3 ng/ml，n = 24，M±SD，P < 0.02；tPA = 6.1±3.2 ng/ml，n = 10，M±SD，P < 0.01），tPA - PAI - C和活性PAI显著升高（tPA - PAI - C = 85.07±50.01 ng/ml，n = 24，P < 0.05；活性PAI = 407.4±166.0 ng/ml，n = 24，P < 0.205），PIC和D - 二聚体升高（PIC = 435.1±145.2 ng/ml，n = 8，M±SD，P < 0.001）。（摘要截断于250字）
