Wang Hao-Ran, Gao Xiang-Rong, Zhang Kai-Gao, Han Ji-Sheng
Neuroscience Research Institute, Peking University, Beijing 100083.
Sheng Li Ke Xue Jin Zhan. 2003 Jul;34(3):202-6.
The central feature of drug addiction is compulsive drug use--loss of control over apparently voluntary acts of drug seeking and drug taking. Drug addiction, as a chronic brain disease, may result from abnormal engagement of long-term associative memory. Addiction and memory are likely to share much in common in the aspects of neural adaptations, synaptic plasticity, and related molecular mechanisms. This paper reviews the possible roles of learning mechanisms in the development of relapse, sensitization, and drug addiction, abnormal associative learning and compulsive behavior, addiction memory and addiction, multiple memory systems and the development of addiction, and emphasize the importance of synaptic plasticity and addiction memory in drug addiction. Addiction is characterized by the involvement of specific learning patterns of information. Addiction is closely related to the disorder of associate learning that depends on dopamine. Hippocampus may play a key role in addiction. At last, we put forward the future directions for research.
药物成瘾的核心特征是强迫性药物使用——对明显自愿的觅药和用药行为失去控制。药物成瘾作为一种慢性脑部疾病，可能源于长期联想记忆的异常参与。成瘾和记忆在神经适应性、突触可塑性及相关分子机制方面可能有许多共同之处。本文综述了学习机制在复发、敏化和药物成瘾发展中的可能作用、异常联想学习与强迫行为、成瘾记忆与成瘾、多个记忆系统与成瘾发展，并强调了突触可塑性和成瘾记忆在药物成瘾中的重要性。成瘾的特征在于特定信息学习模式的参与。成瘾与依赖多巴胺的联想学习障碍密切相关。海马体可能在成瘾中起关键作用。最后，我们提出了未来的研究方向。
