Swerdloff R S, Wang C
Swerdloff, Harbor-UCLA Medical Center, Division of Endocrinology, Box 446, 1000 W. Carson Street, Torrance, CA 90509-2910, USA.
Aging Male. 2003 Sep;6(3):207-11.
Transdermal testosterone gels represent an effective alternative to injectable testosterone preparations. Short-term (6 months) data demonstrated positive effects on muscle, bone, fat, libido and mood. This report provides a preliminary analysis of longer-term treatment with a testosterone gel (AndroGel or Testogel) in a group of men aged 19-67 years of age. The positive effects of testosterone treatment on all of the above parameters persisted in this 3-year follow-up. The benefits occurred independent of age (equally in the older and younger subjects). The positive effects of transdermal testosterone gel on bone mineral density previously identified at 6 months of treatment, continued with time. The positive effects on bone mineral density were greater in the spine than the hip. There were minimal effects on lipid levels. Levels of prostate-specific antigen (PSA) increased with testosterone treatment but, in general, remained in the normal range. Three subjects (1.8%) were shown to have elevated PSA and biopsy-proven prostate cancer. It was not possible to determine if this incidence is above the background rate. Monitoring for prostate disease through PSA measurements and digital rectal examination is recommended for hypogonadal men in the older age groups when treated with testosterone.
经皮睾酮凝胶是注射用睾酮制剂的一种有效替代物。短期（6个月）数据显示其对肌肉、骨骼、脂肪、性欲和情绪有积极影响。本报告对一组年龄在19至67岁的男性使用睾酮凝胶（安特尔凝胶或Testogel）进行长期治疗进行了初步分析。在这3年的随访中，睾酮治疗对上述所有参数的积极影响持续存在。这些益处与年龄无关（在老年和年轻受试者中效果相同）。经皮睾酮凝胶在治疗6个月时对骨矿物质密度的积极影响随时间持续存在。对脊柱骨矿物质密度的积极影响大于髋部。对血脂水平影响极小。睾酮治疗后前列腺特异性抗原（PSA）水平升高，但总体仍在正常范围内。三名受试者（1.8%）PSA升高且经活检证实患有前列腺癌。无法确定该发病率是否高于背景发生率。对于老年性腺功能减退男性接受睾酮治疗时，建议通过PSA测量和直肠指检监测前列腺疾病。
