[肿瘤浸润性树突状细胞与黏蛋白1基因在良性前列腺增生和前列腺癌中的表达]
[Tumor infiltrating dendritic cells and Mucin1 gene expression in benign prostatic hyperplasia and prostate cancer].
作者信息
Xiang Song-Tao, Zhou Si-Wei, Guan Wei, Wang Qin-Zhang, Zhang Bao, Liu Ji-Hong, Ye Zhang-Qun
机构信息
Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.
出版信息
Zhonghua Nan Ke Xue. 2003 Oct;9(7):497-500.
OBJECTIVE
To study the expression of Mucin1 gene and tumor infiltrating dendritic cells(TIDC) in the tissues of benign prostatic hyperplasia (BPH) and prostate cancer.
METHODS
Mucin1 and TIDC were detected in 20 specimens of BPH and 30 specimens of prostate cancer by immunohistochemistry SP method.
RESULTS
MUC1 expressed in both prostate cancer and BPH. The staining patterns were significantly associated with tumor pathological grade (P < 0.001). The number of TIDC was negatively correlated with tumor pathological grade, the higher the grade, the smaller the number of TIDC (P < 0.001).
CONCLUSIONS
The expression pattern of MUC1 and the number of TIDC could be considered as useful markers to evaluate the malignant degree and prognosis of prostate cancer. The decrease of TIDC plays an important role in tumor immune evasion and immune tolerance. Highly expressed MUC1 could lead to the failure of hormonal treatment for prostate cancer, and contribute much to tumor infiltration and metastasis.
目的
研究黏蛋白1基因（Mucin1）和肿瘤浸润树突状细胞（TIDC）在良性前列腺增生（BPH）及前列腺癌组织中的表达情况。
方法
采用免疫组织化学SP法检测20例BPH组织和30例前列腺癌组织中的Mucin1及TIDC。
结果
MUC1在前列腺癌和BPH组织中均有表达。其染色模式与肿瘤病理分级显著相关（P < 0.001）。TIDC数量与肿瘤病理分级呈负相关，分级越高，TIDC数量越少（P < 0.001）。
结论
MUC1的表达模式及TIDC数量可作为评估前列腺癌恶性程度及预后的有用指标。TIDC数量减少在肿瘤免疫逃逸和免疫耐受中起重要作用。MUC1高表达可导致前列腺癌激素治疗失败，并在肿瘤浸润和转移中起重要作用。
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