[Expression and significance of clusterin in normal prostate, benign prostate hyperplasia and prostate cancer].

作者信息

Zhou Li-qun, Yang Xue-zhen, Zeng Li, Liang Li-li, Yang Xin-yu, Ren Liang, Chung Lee, Zhang Zhi-wen, Na Yan-qun, Gu Fang-liu, Guo Ying-lu

机构信息

Institute of Urology, First Hospital, Peking University, Beijing 100034, China.

出版信息

Zhonghua Wai Ke Za Zhi. 2003 Feb;41(2):93-5.

OBJECTIVE

To investigate the expression and significance of Clusterin in normal prostate, benign prostate hyperplasia (BPH) and prostate cancer.

METHODS

Clusterin expression in samples of 12 normal prostate, 15 BPH, and 56 prostate cancer were studied by immunohistochemical stain.

RESULTS

Of 83 cases, 67 are positive or weak positive (81%). The rate of positive or weak positive for normal prostate, BPH and prostate cancer was 17% (2/12), 73% (11/15), and 96% (54/56) respectively. The expression level of Clusterin in prostate cancer was much higher than in normal prostate (t = 8.82, P < 0.01). BPH (t = 7.63, P < 0.01) was related positively with pathological grade (r = 0.649, P < 0.01) and stage (r = 0.609, P < 0.01) of prostate cancer.

CONCLUSION

Clusterin may play an important role in the biological characteristics of prostate cancer by the anti-apoptosis pathway.