Hansel Donna E, Hansel Christian R W, Shindle Michael K, Reinhardt Elsie M, Madden LaVerne, Levey Eric B, Johnston Michael V, Hoon Alexander H
Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
Pediatr Neurol. 2003 Sep;29(3):203-6. doi: 10.1016/s0887-8994(03)00208-x.
Baclofen, a gamma-aminobutyric acid agonist, is widely used to treat spasticity of cerebral and spinal origin. Patients with both acute baclofen overdose and withdrawal have developed seizures. After several reports of new-onset seizures in children treated with oral baclofen at our institution, we reviewed our experience regarding possible effects of baclofen on seizure induction in a childhood movement disorders program over a 2-year period. Of 54 children (ages 1-10) treated with oral baclofen, 19 (35%) had a prior history of seizures. Five children (14%) developed new-onset seizures after starting baclofen. Although epilepsy is very common in children with cerebral palsy, these findings raise the possibility that baclofen may potentiate seizures in certain young children with cerebral palsy. Further study of the effects of baclofen on seizures is warranted.
巴氯芬，一种γ-氨基丁酸激动剂，被广泛用于治疗脑源性和脊髓源性痉挛。急性巴氯芬过量和戒断的患者都出现过癫痫发作。在我们机构有几例使用口服巴氯芬治疗的儿童出现新发癫痫的报告后，我们回顾了我们在一个为期两年的儿童运动障碍项目中关于巴氯芬对癫痫诱发可能影响的经验。在54名接受口服巴氯芬治疗的儿童（年龄1至10岁）中，19名（35%）有癫痫发作史。5名儿童（14%）在开始使用巴氯芬后出现新发癫痫。虽然癫痫在脑瘫儿童中非常常见，但这些发现增加了巴氯芬可能使某些患有脑瘫的幼儿癫痫发作加重的可能性。有必要进一步研究巴氯芬对癫痫发作的影响。
