Ohashi Pamela S
Ontario Cancer Institute, University Health Network, 610 University Avenue, Toronto ON M5G 2M9 Canada.
Curr Opin Immunol. 2003 Dec;15(6):668-76. doi: 10.1016/j.coi.2003.09.013.
The impaired elimination of self-reactive T cells is one factor that contributes to autoimmunity. Although the mechanism of thymic negative selection has been studied for decades, recent data demonstrate that the mechanisms underlying this fundamental process remain extremely controversial. Nonetheless, new models such as the Aire-deficient mice have demonstrated the importance of thymic negative selection in autoimmune disease progression in mice and humans.
自身反应性T细胞清除功能受损是导致自身免疫的一个因素。尽管胸腺阴性选择的机制已研究了数十年，但最近的数据表明，这一基本过程的潜在机制仍极具争议性。尽管如此，诸如Aire缺陷小鼠等新模型已证明胸腺阴性选择在小鼠和人类自身免疫性疾病进展中的重要性。
