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针刺伤和性暴露后的紧急预防:一项比较纽约急诊科医生与其全国同行的调查结果

Emergency prophylaxis following needle-stick injuries and sexual exposures: results from a survey comparing New York Emergency Department practitioners with their national colleagues.

作者信息

Merchant Roland C, Keshavarz Reza

机构信息

Department of Emergency Medicine, Mount Sinai School of Medicine, New York, NY, USA.

出版信息

Mt Sinai J Med. 2003 Oct;70(5):338-43.

Abstract

BACKGROUND

Emergency prophylaxis following needle-stick and sexual exposures includes HIV post-exposure prophylaxis, hepatitis B prophylaxis and emergency contraception. The Centers for Disease Control and Prevention endorse HIV post-exposure and hepatitis B prophylaxis for health care workers, and hepatitis B prophylaxis and emergency contraception after sexual assault. The New York State Department of Health advocates HIV post-exposure prophylaxis after sexual assault. This study compares emergency department practitioners in New York State (NYS) with those from other states in their willingness to offer emergency prophylaxis after needle-stick and sexual exposures, and their self-reported history of prescribing and using HIV post-exposure prophylaxis.

METHODS

The authors surveyed emergency department practitioners from across the US at the American College of Emergency Physicians 2000 Scientific Assembly. The questionnaire included clinical scenarios describing different patients who present to the emergency department within one hour of a needle-stick injury, sexual assault or consensual sexual encounter, and had questions on the practitioners self-reported prescribing and usage of HIV post-exposure prophylaxis. For each scenario the practitioners were asked to indicate if they would offer emergency prophylaxis to different patients at varied HIV risk levels. The data were processed through SPSS 10.0.

RESULTS

Of the 600 respondents, 100 were from NYS. In the clinical scenarios, NYS practitioners were more likely than other US practitioners to offer HIV post-exposure prophylaxis for exposures to unknown and low HIV risk sources (p<0.05) and to offer hepatitis B prophylaxis in most of the sexual exposure scenarios (p<0.01). All practitioners offered HIV post-exposure and hepatitis B prophylaxis less often after consensual sexual encounters than after sexual assault and needle-stick injuries. In most cases, NYS practitioners were more willing to offer emergency contraception after sexual assault and consensual sexual encounters than were other practitioners (p<0.05). In terms of self-reported prescribing of HIV post-exposure prophylaxis, NYS practitioners had prescribed HIV post-exposure prophylaxis after sexual assault (p<0.001) and non-health-care-worker needle-stick injuries (p<0.05) much more often than did other practitioners.

CONCLUSIONS

Compared to their national colleagues, NYS emergency department practitioners were generally more willing to offer all forms of emergency prophylaxis after sexual assault. They also reported having had more experience than other practitioners in prescribing HIV post-exposure prophylaxis. Although most practitioners were clearly willing to offer HIV post-exposure prophylaxis for nonoccupational exposures, NYS practitioners were less willing to offer emergency prophylaxis following consensual sex than after sexual assault. These findings suggest that the NYS guidelines for HIV post-exposure prophylaxis after sexual assault may have influenced emergency practitioners willingness to offer and prescribe prophylaxis.

摘要

背景

针刺伤和性暴露后的紧急预防措施包括艾滋病病毒暴露后预防、乙型肝炎预防和紧急避孕。疾病控制与预防中心认可医护人员进行艾滋病病毒暴露后预防和乙型肝炎预防,以及性侵犯后进行乙型肝炎预防和紧急避孕。纽约州卫生部提倡性侵犯后进行艾滋病病毒暴露后预防。本研究比较了纽约州(NYS)与其他州的急诊科医生在针刺伤和性暴露后提供紧急预防措施的意愿,以及他们自我报告的艾滋病病毒暴露后预防用药和用药史。

方法

作者在美国急诊医师学会2000年科学大会上对来自美国各地的急诊科医生进行了调查。问卷包括临床场景描述,即不同患者在针刺伤、性侵犯或双方自愿性行为后一小时内到急诊科就诊的情况,并就医生自我报告的艾滋病病毒暴露后预防用药和用药情况提出问题。对于每个场景,要求医生表明是否会为不同艾滋病病毒风险水平的患者提供紧急预防措施。数据通过SPSS 10.0进行处理。

结果

600名受访者中,100名来自纽约州。在临床场景中,纽约州的医生比其他美国医生更有可能为接触未知和低艾滋病病毒风险源的情况提供艾滋病病毒暴露后预防(p<0.05),并且在大多数性暴露场景中更有可能提供乙型肝炎预防(p<0.01)。与性侵犯和针刺伤后相比,所有医生在双方自愿性行为后提供艾滋病病毒暴露后预防和乙型肝炎预防的频率更低。在大多数情况下,纽约州的医生比其他医生更愿意在性侵犯和双方自愿性行为后提供紧急避孕(p<0.05)。就自我报告的艾滋病病毒暴露后预防用药情况而言,纽约州的医生在性侵犯后(p<0.001)和非医护人员针刺伤后(p<0.05)开具艾滋病病毒暴露后预防药物的频率比其他医生高得多。

结论

与全国其他同事相比,纽约州急诊科医生通常更愿意在性侵犯后提供所有形式的紧急预防措施。他们还报告说,在开具艾滋病病毒暴露后预防药物方面比其他医生有更多经验。尽管大多数医生显然愿意为非职业暴露提供艾滋病病毒暴露后预防,但纽约州的医生在双方自愿性行为后比在性侵犯后更不愿意提供紧急预防措施。这些发现表明,纽约州性侵犯后艾滋病病毒暴露后预防指南可能影响了急诊医生提供和开具预防药物的意愿。

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