Gimmel'farb G N, Popova I Iu, Iunusova S B
Anesteziol Reanimatol. 1992 May-Jun(3):35-7.
Blood plasma levels of "pain substances" (serotonin, histamine, prostaglandin F2 alpha, adrenaline /A/) and neuropeptides (beta-endorphin, somatostatin) have been evaluated in 39 patients during the early postoperative period after lung and mediastinum surgery. The studies have shown that the content of these biologically active substances increases considerably. Following stellate ganglion blockade A concentration decreased significantly, the uptake of narcotic analgesics used for postoperative analgesia reduced 1.7-fold, however the levels of "pain substances" and neuropeptides remained unchanged. It is believed that postoperative pain syndrome develops due to the elevation of the levels of the substances under study. Stellate ganglion blockade produces only sympatholytic effect, which shows the necessity of the elaboration of drug therapeutic techniques blocking "pain" receptors and using "pain substance" antagonists.
对39例肺和纵隔手术后早期的患者，评估了血浆中“疼痛物质”（血清素、组胺、前列腺素F2α、肾上腺素/A/）和神经肽（β-内啡肽、生长抑素）的水平。研究表明，这些生物活性物质的含量显著增加。星状神经节阻滞后，A浓度显著降低，用于术后镇痛的麻醉性镇痛药的用量减少了1.7倍，然而“疼痛物质”和神经肽的水平保持不变。据信，术后疼痛综合征是由于所研究物质水平的升高而产生的。星状神经节阻滞仅产生交感神经阻滞作用，这表明有必要研发阻断“疼痛”受体并使用“疼痛物质”拮抗剂的药物治疗技术。
