[The role of humoral factors in the mechanism of the analgesic effect of electroacupuncture].

An experimental model of acute painful trauma under electroacupuncture (EAP) protection was established. During the first 15 minutes of acute pain and EAP F2 alpha-prostaglandin, serotonin, and histamine concentrations decreased in arterial blood corresponding to increased concentrations of endogenous opiates in cerebrospinal fluid. In 30 minutes of acute pain and EAP the concentration of opiates (methionine-enkephaline, leucine-enkephaline) begins to decrease, but F2 alpha-prostaglandine, serotonin and histamine content increases significantly. The concentration of cyclic nucleotides changes significantly at investigation stages. However, they are not significant in EAP mechanism, but they are modulators of endogenous opiate effects and implement interaction between them and prostaglandines. We consider that the analgetic effect caused by EAP under acute surgical trauma is connected not only with endogenous opiate system activation, but with synthesis suppression of "pain substances".