Himmelfarb G N, Schumilowa I J
Abteilung für Anästhesiologie, Reanimation und Intensivtherapie, Akademie der Medizinischen Wissenschaften der UdSSR.
Anaesthesiol Reanim. 1990;15(3):145-50.
An experimental model of acute painful trauma under electroacupuncture (EAP) protection was established. During the first 15 minutes of acute pain and EAP F2 alpha-prostaglandin, serotonin, and histamine concentrations decreased in arterial blood corresponding to increased concentrations of endogenous opiates in cerebrospinal fluid. In 30 minutes of acute pain and EAP the concentration of opiates (methionine-enkephaline, leucine-enkephaline) begins to decrease, but F2 alpha-prostaglandine, serotonin and histamine content increases significantly. The concentration of cyclic nucleotides changes significantly at investigation stages. However, they are not significant in EAP mechanism, but they are modulators of endogenous opiate effects and implement interaction between them and prostaglandines. We consider that the analgetic effect caused by EAP under acute surgical trauma is connected not only with endogenous opiate system activation, but with synthesis suppression of "pain substances".
建立了电针（EAP）保护下急性疼痛创伤的实验模型。在急性疼痛和EAP的最初15分钟内，动脉血中F2α-前列腺素、血清素和组胺浓度降低，同时脑脊液中内源性阿片类物质浓度升高。在急性疼痛和EAP 30分钟时，阿片类物质（甲硫氨酸脑啡肽、亮氨酸脑啡肽）浓度开始降低，但F2α-前列腺素、血清素和组胺含量显著增加。在研究阶段，环核苷酸浓度有显著变化。然而，它们在EAP机制中并不显著，但它们是内源性阿片类物质作用的调节剂，并实现它们与前列腺素之间的相互作用。我们认为，EAP在急性外科创伤下引起的镇痛作用不仅与内源性阿片类物质系统激活有关，还与“疼痛物质”的合成抑制有关。
