Seeber S, Schilcher R B, Brucksch K P, Käding J, Schmidt C G
Z Krebsforsch Klin Onkol Cancer Res Clin Oncol. 1977 Dec 15;90(3):307-12. doi: 10.1007/BF00284304.
The cytostatic efficacy of the antibiotics adriamycin, daunomycin and actinomycin D and of DNA-complexes of these compounds was compared in an Ehrlich ascites tumor in vivo. Various doses of the individual drugs and their DNA-complexes were injected intraperitoneally into female NMRI mice following 8 days after inoculation of 10(6) Ehrlich ascites cells. Survival analyses of animals demonstrated that by addition of DNA therapeutic indices were improved for adriamycin, daunomycin and actinomycin D, DNA alone had no effect on this tumor. Since earlier biochemical data (Seeber et al., 1977) had shown decreased in vitro cytotoxicity of DNA-bound antibiotics, this increase in therapeutic efficacy is probably due to an altered pharmacological behaviour after complex formation with a prolongation of effective intraperitoneal drug levels and decreased systemic toxicity.
在体内艾氏腹水瘤中比较了抗生素阿霉素、柔红霉素和放线菌素D以及这些化合物的DNA复合物的细胞生长抑制功效。在接种10⁶个艾氏腹水细胞8天后，将不同剂量的各药物及其DNA复合物腹腔注射到雌性NMRI小鼠体内。动物生存分析表明，通过添加DNA，阿霉素、柔红霉素和放线菌素D的治疗指数得到改善，单独的DNA对该肿瘤没有影响。由于早期的生化数据（西伯等人，1977年）显示与DNA结合的抗生素体外细胞毒性降低，这种治疗效果的提高可能是由于与DNA形成复合物后药理行为发生改变，有效腹腔内药物水平延长且全身毒性降低。
