Okada Mitsuru, Yanagida Hidehiko, Kuwajima Hiroaki, Takemura Tsukasa
Department of Pediatrics, Kinki University School of Medicine, 377-2 Ohno-higashi, Osaka-Sayama 589-8511, Japan.
Pediatr Nephrol. 2004 Jan;19(1):26-32. doi: 10.1007/s00467-003-1306-y. Epub 2003 Nov 22.
Treatment with hydroxymethylglutaryl coenzyme A reductase inhibitors and thiazolidinedione derivatives may prevent the development of diabetic nephropathy. The precise mechanisms of the beneficial effects of these agents in mesangial cells are uncertain. We cultured mesangial cells from Otsuka Long-Evans Tokushima Fatty (OLETF) rats, a model for human type 2 diabetes mellitus. The effects of fluvastatin and/or troglitazone on DNA synthesis were determined. Fluvastatin in combination with troglitazone markedly inhibited DNA synthesis and induced apoptosis in mesangial cells from OLETF rats. Combined therapy with fluvastatin and thiazolidinedione derivatives may be effective for suppression of mesangial cell proliferation in the early phase of diabetes, thereby possibly slowing the evolution of diabetic glomerulopathy.
使用羟甲基戊二酰辅酶A还原酶抑制剂和噻唑烷二酮衍生物进行治疗可能会预防糖尿病肾病的发展。这些药物对系膜细胞产生有益作用的确切机制尚不清楚。我们培养了大冢长-艾氏糖尿病大鼠（OLETF大鼠）的系膜细胞，该大鼠是人类2型糖尿病的模型。测定了氟伐他汀和/或曲格列酮对DNA合成的影响。氟伐他汀与曲格列酮联合使用可显著抑制OLETF大鼠系膜细胞的DNA合成并诱导其凋亡。氟伐他汀与噻唑烷二酮衍生物联合治疗可能对抑制糖尿病早期系膜细胞增殖有效，从而可能减缓糖尿病肾小球病变的进展。
