Steinhart H, Kleinsasser O
Klinik für Hals-, Nasen-, Ohrenheilkunde, Kopf- und Halschirurgie Philipps Universität Marburg/Lahn.
Laryngorhinootologie. 1992 Nov;71(11):556-60. doi: 10.1055/s-2007-997354.
The records of 68 patients with cancer of the floor of the mouth were reviewed. 56 patients underwent surgical management, 51 of them got additionally postoperative radiation. The tumour-specific five years' survival for patients with operation was 46%, 57% of treatment failures developed from local recurrence of the tumour. In 52% of all cases there was a spread to the lymphatic system in the histological evaluation. There was high incidence of false negative clinical examinations of the neck. Conservative neck dissection was the procedure of choice for clinically positive lymph nodes and for the elective management of the neck. Only advanced tumours showed involvement of the mandibular bone. Therefore a conservative management of mandibular resection was preferred. Radical tumour extirpation and histological controlling with serial sectioned specimens are methods of avoiding local tumour recurrence.
回顾了68例口底癌患者的记录。56例患者接受了手术治疗,其中51例术后还接受了放疗。手术患者的肿瘤特异性5年生存率为46%,57%的治疗失败是由肿瘤局部复发引起的。在所有病例中,52%在组织学评估中有淋巴系统转移。颈部临床检查假阴性的发生率很高。保守性颈清扫术是临床阳性淋巴结和颈部选择性治疗的首选方法。只有晚期肿瘤显示下颌骨受累。因此,首选下颌骨切除术的保守治疗方法。根治性肿瘤切除和用连续切片标本进行组织学控制是避免局部肿瘤复发的方法。