Harnett M, Rigley K
Dept of Biochemistry, University of Glasgow, UK.
Immunol Today. 1992 Dec;13(12):482-6. doi: 10.1016/0167-5699(92)90022-Y.
The relative roles of G-proteins and protein tyrosine kinases (PTKs) in the regulation of antigen receptor-mediated signalling in B and T cells is controversial. As they, and the biochemical events they control, are potential targets for intervention in various immune dysfunctions, the resolution of the controversy is of great interest. Here, Margaret Harnett and Kevin Rigley provide a timely assessment of current understanding, and propose a model for the interaction of G-proteins and PTKs in antigen receptor-mediated signalling.
G蛋白和蛋白酪氨酸激酶（PTK）在B细胞和T细胞抗原受体介导的信号传导调节中的相对作用存在争议。由于它们以及它们所控制的生化事件是干预各种免疫功能障碍的潜在靶点，解决这一争议备受关注。在此，玛格丽特·哈内特和凯文·里格利及时评估了当前的理解情况，并提出了一个G蛋白和PTK在抗原受体介导的信号传导中相互作用的模型。
