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粒细胞-巨噬细胞集落刺激因子、白细胞介素-3和白细胞介素-5：对人造血细胞的交叉竞争

GM-CSF, IL-3 and IL-5: cross-competition on human haemopoietic cells.

作者信息

Lopez A F, Elliott M J, Woodcock J, Vadas M A

机构信息

Hanson Centre for Cancer Research, Institute of Medical & Veterinary Science, Adelaide, Australia.

出版信息

Immunol Today. 1992 Dec;13(12):495-500. doi: 10.1016/0167-5699(92)90025-3.

DOI:10.1016/0167-5699(92)90025-3
PMID:1463582
Abstract

The biological properties of GM-CSF, IL-3 and IL-5 are multiple; initially described as haemopoietic growth factors, they also regulate inflammation, allergic reactions and cell adherence. The receptors for these three cytokines share a common component which may play a key role in their biological activity. This review describes the potential roles of GM-CSF, IL-3 and IL-5 in inflammation and discusses approaches to modulate their function.

摘要

粒细胞-巨噬细胞集落刺激因子（GM-CSF）、白细胞介素-3（IL-3）和白细胞介素-5（IL-5）具有多种生物学特性；它们最初被描述为造血生长因子，还可调节炎症、过敏反应和细胞黏附。这三种细胞因子的受体共有一个共同成分，该成分可能在其生物学活性中起关键作用。本综述描述了GM-CSF、IL-3和IL-5在炎症中的潜在作用，并讨论了调节其功能的方法。

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