Pate J L
Ohio State University/OARDC, 1680 Madison Ave, Wooster, OH 44691, USA.
Reprod Suppl. 2003;61:207-17.
This review focuses on factors that may affect the sensitivity of the corpus luteum to uterine prostaglandin F2alpha (PGF2alpha) and embryonic signals. The heterogeneity of the types of cell that are present within the corpus luteum results in complex interactions that ensure complete luteal regression in response to PGF2alpha. There is not likely to be a single factor that determines responsiveness. The sensitivity of the corpus luteum depends on the proper balance of a variety of factors that are involved in mediating the effects of PGF2alpha. This balance is achieved as the early corpus luteum undergoes development, but may also be altered by embryonic factors to rescue the corpus luteum during early pregnancy.
本综述聚焦于可能影响黄体对子宫前列腺素F2α（PGF2α）和胚胎信号敏感性的因素。黄体中存在的细胞类型的异质性导致了复杂的相互作用，以确保对PGF2α作出反应时黄体完全退化。不太可能存在单一因素决定反应性。黄体的敏感性取决于多种参与介导PGF2α作用的因素的适当平衡。这种平衡在早期黄体发育过程中得以实现，但在妊娠早期也可能因胚胎因素而改变，从而挽救黄体。
