Leppik Ilo E, Biton Victor, Sander Josemir W A, Wieser Heinz Gregor
MINCEP Epilepsy Care and University of Minnesota, 5775 Wayzata Boulevard, Suite 255, Minneapolis, MN 55416, USA.
Epilepsia. 2003 Dec;44(12):1585-7. doi: 10.1111/j.0013-9580.2003.00403.x.
To determine the effect of levetiracetam (LEV) on partial seizure subtypes (simple partial, complex partial, and secondarily generalized seizures) in patients with refractory epilepsy.
Pooled results from three placebo-controlled trials were analyzed.
A statistically significant reduction in the frequency of all partial seizures and all seizure subtypes was observed in the LEV group (p < 0.001 vs. placebo). The proportion of patients in whom secondarily generalized seizures could be prevented over and above the reduction of partial seizures was significantly greater in the LEV group as compared with placebo, with an odds ratio of 1.83 [95% confidence interval (CI), 1.10-3.05]. CONCLUSIONS; LEV reduces frequency of simple and complex partial seizures. In addition, it demonstrates a specific, independent reduction of secondarily generalized seizures.
确定左乙拉西坦（LEV）对难治性癫痫患者部分性癫痫发作亚型（简单部分性发作、复杂部分性发作和继发性全身性发作）的影响。
分析了三项安慰剂对照试验的汇总结果。
LEV组所有部分性癫痫发作及所有发作亚型的频率均有统计学意义的降低（与安慰剂相比，p < 0.001）。与安慰剂相比，LEV组中除部分性癫痫发作减少外还能预防继发性全身性发作的患者比例显著更高，优势比为1.83 [95%置信区间（CI），1.10 - 3.05]。结论：LEV可降低简单和复杂部分性癫痫发作的频率。此外，它还能特异性、独立地减少继发性全身性发作。
