Temple Sally
Albany Medical College, Albany, NY 12208, USA.
Cell. 2003 Oct 31;115(3):247-8. doi: 10.1016/s0092-8674(03)00853-5.
Maintaining the pluripotency of mouse ES cells requires both LIF (leukemia inhibitory factor) and unknown factors in serum. The paper from Ying et al. in this issue of Cell shows that BMP (bone morphogenetic protein) can replace serum in this capacity, defining molecular requirements for ES cell self-renewal.
维持小鼠胚胎干细胞的多能性既需要白血病抑制因子（LIF），也需要血清中的未知因子。Ying等人在本期《细胞》杂志上发表的论文表明，骨形态发生蛋白（BMP）可以在这方面替代血清，从而明确了胚胎干细胞自我更新的分子条件。
