莫洛尼鼠白血病病毒逆转录酶调节其自身的表达。
MoMLV reverse transcriptase regulates its own expression.
作者信息
Bradley Christina, Craigie Robert
机构信息
Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 20892, Bethesda, MD, USA
出版信息
Cell. 2003 Oct 31;115(3):250-1. doi: 10.1016/s0092-8674(03)00850-x.
Abstract
A precise ratio of Gag:Gag-Pol expression is required for assembly of infectious retroviral virions. In this issue of Cell, Orlova et al. show that MoMLV reverse transcriptase binds the translation release factor eRF1, and that this interaction promotes translation readthrough to make Gag-Pol.
摘要
传染性逆转录病毒病毒粒子的组装需要Gag:Gag-Pol表达的精确比例。在本期《细胞》杂志中，奥尔洛娃等人表明，莫洛尼鼠白血病病毒逆转录酶与翻译释放因子eRF1结合，这种相互作用促进翻译通读以产生Gag-Pol。
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