Yoon J H, Yook J I, Kim H J, Cha I H, Yang W I, Kim J
Department of Oral Pathology, College of Dentistry, Chosun University, Gwangju, Korea.
Int J Oral Maxillofac Surg. 2003 Dec;32(6):664-6. doi: 10.1054/ijom.2002.0416.
A solitary plasmacytoma occurring in the mandible of a 15-year-old Korean male 6 years after renal transplantation is reported. The tumour presented as a hyperplastic gingival overgrowth in the right madibular molar area. Histology and immunohistochemistry revealed plasmacytoma and monoclonality of the kappa chain and IgG. In situ hybridization for Epstein-Barr virus encoded RNA (EBER) showed positive signals in the tumour cells. The tumour regressed after reducing the immunosuppressive agents with concurrent radiotherapy. The patient remains in a stable condition with normal renal functions after 7 years without recurrence. This case confirms that Epstein-Barr virus associated B-lymphoproliferative disorders are still a major complication of immunosuppression.
报告了一名15岁韩国男性肾移植6年后发生在下颌骨的孤立性浆细胞瘤。肿瘤表现为右下颌磨牙区增生性牙龈过度生长。组织学和免疫组化显示为浆细胞瘤，κ链和IgG呈单克隆性。爱泼斯坦-巴尔病毒编码RNA（EBER）原位杂交在肿瘤细胞中显示阳性信号。在减少免疫抑制剂并同时进行放疗后，肿瘤消退。7年后患者肾功能正常，病情稳定，无复发。该病例证实爱泼斯坦-巴尔病毒相关的B淋巴细胞增殖性疾病仍然是免疫抑制的主要并发症。
