Yamada Yasuhiko, Endo Shigeatsu, Nakae Hajime, Makabe Hideyuki, Sato Nobuhiro, Wakabayashi Go, Kitamura Michihiko, Inada Katsuya, Sato Shigehiro
Department of Critical Care Medicine, Iwate Medical University School of Medicine, 19-1 Uchimaru, 020-8505, Morioka, Japan.
Burns. 2003 Dec;29(8):799-802. doi: 10.1016/s0305-4179(03)00201-8.
The FasL-Fas system is one of the recognized apoptosis-inducing systems, and has been determined to have important functions in relation to homeostasis and biological defense mechanisms. In this study, we investigated the serum levels of soluble Fas (sFas), soluble FasL (sFasL) and tumor necrosis factor alpha (TNF-alpha) in patients with burns. The sFas levels were found to be significantly higher in the patients who eventually died as compared to those in the patients who survived (3.9+/-1.8ng/ml versus 2.6+/-1.0ng/ml). On the other hand, the sFasL levels were significantly higher in the patients who survived (61.5+/-29.9ng/ml versus 37.2+/-14.4ng/ml) than in those who eventually died. A positive correlation was noted between the TNF-alpha level and the sFas level, and a negative correlation was observed between the TNF-alpha level and the sFasL level. These findings suggest that worsening of the condition of a burns patient may be related to changes in the Fas-FasL system.
FasL-Fas系统是公认的诱导细胞凋亡的系统之一，并且已被确定在体内平衡和生物防御机制方面具有重要作用。在本研究中，我们调查了烧伤患者血清中可溶性Fas（sFas）、可溶性FasL（sFasL）和肿瘤坏死因子α（TNF-α）的水平。结果发现，最终死亡的患者的sFas水平显著高于存活患者（3.9±1.8ng/ml对2.6±1.0ng/ml）。另一方面，存活患者的sFasL水平（61.5±29.9ng/ml对37.2±14.4ng/ml）显著高于最终死亡的患者。TNF-α水平与sFas水平呈正相关，而TNF-α水平与sFasL水平呈负相关。这些发现表明，烧伤患者病情的恶化可能与Fas-FasL系统的变化有关。
