Vergnes Marguerite, Boehrer Any, Nehlig Astrid
INSERM U 398, Faculty of Medicine, 11 rue Humann, 67085, Strasbourg Cedex, France.
Exp Neurol. 2003 Nov;184(1):549-51. doi: 10.1016/s0014-4886(03)00098-0.
Adult rats with genetic absence epilepsy (GAERS) were shown to be hyperresponsive to convulsions induced by picrotoxin compared to nonepileptic controls (NERs). In contrast, young GAERS aged 22-26 days were less responsive than NERs to picrotoxin-induced convulsions. Around 30 days of age, when spontaneous spike-wave discharges develop in GAERS, the sensitivity of both strains did no longer differ. After 40 days of age, GAERS appeared definitely more prone than NERs to convulse in response to picrotoxin injection. A developmental imbalance in excitation/inhibition may parallel the occurrence of SWDs.
与非癫痫对照大鼠（NERs）相比，遗传性失神癫痫（GAERS）成年大鼠对印防己毒素诱导的惊厥反应过度。相比之下，22 - 26日龄的年轻GAERS大鼠对印防己毒素诱导的惊厥反应比NERs大鼠弱。在大约30日龄时，GAERS大鼠出现自发性棘波 - 慢波放电，此时两个品系的敏感性不再有差异。40日龄后，GAERS大鼠对印防己毒素注射诱发惊厥的易感性明显高于NERs大鼠。兴奋/抑制的发育失衡可能与棘波 - 慢波放电的出现平行。
