• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

下丘脑进食与代谢信号的整合:聚焦神经肽Y

Integration of hypothalamic feeding and metabolic signals: focus on neuropeptide Y.

作者信息

Currie Paul J

机构信息

Department of Psychology, Barnard College, Columbia University, 3009 Broadway, New York, NY 10027, USA.

出版信息

Appetite. 2003 Dec;41(3):335-7. doi: 10.1016/j.appet.2003.08.011.

DOI:10.1016/j.appet.2003.08.011
PMID:14637334
Abstract

Research is reviewed on effects of neuropeptide Y (NPY) on energy substrate utilization and central interactions among NPY, serotonin and urocortin, particularly in neurons of the paraventricular nucleus of the hypothalamus.

摘要

对神经肽Y(NPY)对能量底物利用的影响以及NPY、血清素和尿皮质素之间的中枢相互作用进行了综述,特别是在下丘脑室旁核的神经元中。

相似文献

1
Integration of hypothalamic feeding and metabolic signals: focus on neuropeptide Y.下丘脑进食与代谢信号的整合:聚焦神经肽Y
Appetite. 2003 Dec;41(3):335-7. doi: 10.1016/j.appet.2003.08.011.
2
Integration of NPY, AGRP, and melanocortin signals in the hypothalamic paraventricular nucleus: evidence of a cellular basis for the adipostat.下丘脑室旁核中神经肽Y、刺鼠相关蛋白和黑皮质素信号的整合:脂肪稳态细胞基础的证据。
Neuron. 1999 Sep;24(1):155-63. doi: 10.1016/s0896-6273(00)80829-6.
3
Hypothalamic neuropeptide Y regulation of feeding and energy metabolism.下丘脑神经肽Y对进食与能量代谢的调节
Curr Opin Neurobiol. 1992 Dec;2(6):847-51. doi: 10.1016/0959-4388(92)90144-a.
4
Metabolic actions of neuropeptide Y and their relevance to obesity.
Biochem Soc Trans. 1996 May;24(2):576-81. doi: 10.1042/bst0240576.
5
Urocortin I inhibits the effects of ghrelin and neuropeptide Y on feeding and energy substrate utilization.孤啡肽 I 抑制胃饥饿素和神经肽 Y 对摄食和能量底物利用的影响。
Brain Res. 2011 Apr 18;1385:127-34. doi: 10.1016/j.brainres.2011.01.114.
6
Hypothalamic paraventricular 5-hydroxytryptamine: receptor-specific inhibition of NPY-stimulated eating and energy metabolism.下丘脑室旁核5-羟色胺:对神经肽Y刺激的进食和能量代谢的受体特异性抑制作用
Pharmacol Biochem Behav. 2002 Apr;71(4):709-16. doi: 10.1016/s0091-3057(01)00671-2.
7
Increased feeding and neuropeptide Y (NPY) but not NPY mRNA levels in the hypothalamus of the rat following central administration of the serotonin synthesis inhibitor p-chlorophenylalanine.在向大鼠中枢给予血清素合成抑制剂对氯苯丙氨酸后,大鼠下丘脑的进食增加且神经肽Y(NPY)增加,但NPY mRNA水平未增加。
Brain Res. 1996 Jun 17;724(2):232-7. doi: 10.1016/0006-8993(96)00329-0.
8
Elevated neuropeptide Y in the arcuate nucleus of young obese Zucker rats may contribute to the development of their overeating.年轻肥胖的 Zucker 大鼠弓状核中神经肽 Y 水平升高可能导致它们暴饮暴食。
J Nutr. 1993 Jun;123(6):1168-72. doi: 10.1093/jn/123.6.1168.
9
Inhibition of neuropeptide Y (NPY)-induced feeding and c-Fos response in magnocellular paraventricular nucleus by a NPY receptor antagonist: a site of NPY action.神经肽Y受体拮抗剂对神经肽Y诱导的进食及大细胞室旁核中c-Fos反应的抑制作用:神经肽Y的作用位点
Endocrinology. 1999 Oct;140(10):4494-500. doi: 10.1210/endo.140.10.7058.
10
Injection of anti-neuropeptide Y gamma-globulin into the hypothalamic paraventricular nucleus decreases food intake in rats.向大鼠下丘脑室旁核注射抗神经肽Yγ球蛋白可减少其食物摄入量。
Brain Res. 1993 Jan 22;601(1-2):313-6. doi: 10.1016/0006-8993(93)91727-a.

引用本文的文献

1
Insulin and obesity transform hypothalamic-pituitary-adrenal axis stemness and function in a hyperactive state.胰岛素和肥胖使下丘脑-垂体-肾上腺轴在高活性状态下具有干细胞特性和功能。
Mol Metab. 2021 Jan;43:101112. doi: 10.1016/j.molmet.2020.101112. Epub 2020 Nov 4.
2
Metabolic Effects of Social Isolation in Adult C57BL/6 Mice.成年C57BL/6小鼠社会隔离的代谢效应
Int Sch Res Notices. 2014 Nov 26;2014:690950. doi: 10.1155/2014/690950. eCollection 2014.
3
Food intake inhibition in rainbow trout induced by activation of serotonin 5-HT2C receptors is associated with increases in POMC, CART and CRF mRNA abundance in hypothalamus.
通过激活血清素5-HT2C受体诱导虹鳟鱼食物摄入抑制与下丘脑促黑素原(POMC)、可卡因-安非他明调节转录肽(CART)和促肾上腺皮质激素释放因子(CRF)mRNA丰度增加有关。
J Comp Physiol B. 2016 Apr;186(3):313-21. doi: 10.1007/s00360-016-0961-9. Epub 2016 Jan 29.
4
Eating behavior and stress: a pathway to obesity.饮食行为与压力:通往肥胖之路。
Front Psychol. 2014 May 13;5:434. doi: 10.3389/fpsyg.2014.00434. eCollection 2014.
5
Perinatal programming of neuroendocrine mechanisms connecting feeding behavior and stress.围产期编程连接摄食行为和应激的神经内分泌机制。
Front Neurosci. 2013 Jun 17;7:109. doi: 10.3389/fnins.2013.00109. eCollection 2013.
6
Identification, characterization and feeding response of peptide YYb (PYYb) gene in grass carp (Ctenopharyngodon idellus).草鱼(Ctenopharyngodon idellus)中肽YYb(PYYb)基因的鉴定、特征分析及摄食反应
Fish Physiol Biochem. 2014 Feb;40(1):45-55. doi: 10.1007/s10695-013-9822-6. Epub 2013 Jun 19.
7
Ghrelin is an orexigenic peptide and elicits anxiety-like behaviors following administration into discrete regions of the hypothalamus.胃饥饿素是一种食欲肽,在被注射到下丘脑的不同区域后会引起类似焦虑的行为。
Behav Brain Res. 2012 Jan 1;226(1):96-105. doi: 10.1016/j.bbr.2011.08.037. Epub 2011 Sep 2.
8
Urocortin I inhibits the effects of ghrelin and neuropeptide Y on feeding and energy substrate utilization.孤啡肽 I 抑制胃饥饿素和神经肽 Y 对摄食和能量底物利用的影响。
Brain Res. 2011 Apr 18;1385:127-34. doi: 10.1016/j.brainres.2011.01.114.
9
Hypothalamic paraventricular 5-hydroxytryptamine inhibits the effects of ghrelin on eating and energy substrate utilization.下丘脑室旁核 5-羟色胺抑制胃饥饿素对摄食和能量底物利用的影响。
Pharmacol Biochem Behav. 2010 Nov;97(1):152-5. doi: 10.1016/j.pbb.2010.05.027. Epub 2010 Jun 2.
10
Serotonergic drugs : effects on appetite expression and use for the treatment of obesity.血清素能药物:对食欲表达的影响及在肥胖治疗中的应用
Drugs. 2007;67(1):27-55. doi: 10.2165/00003495-200767010-00004.