甘露糖基糖树状结构在顺式和反式中均抑制DC-SIGN介导的埃博拉病毒感染。
Mannosyl glycodendritic structure inhibits DC-SIGN-mediated Ebola virus infection in cis and in trans.
作者信息
Lasala Fátima, Arce Eva, Otero Joaquín R, Rojo Javier, Delgado Rafael
机构信息
Laboratorio de Microbiología Molecular, Servicio de Microbiología, Hospital Universitario 12 de Octubre, Madrid, Spain.
出版信息
Antimicrob Agents Chemother. 2003 Dec;47(12):3970-2. doi: 10.1128/AAC.47.12.3970-3972.2003.
Abstract
We have designed a glycodendritic structure, BH30sucMan, that blocks the interaction between dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin (DC-SIGN) and Ebola virus (EBOV) envelope. BH30sucMan inhibits DC-SIGN-mediated EBOV infection at nanomolar concentrations. BH30sucMan may counteract important steps of the infective process of EBOV and, potentially, of microorganisms shown to exploit DC-SIGN for cell entry and infection.
摘要
我们设计了一种糖树状结构，即BH30sucMan，它可阻断树突状细胞特异性细胞间黏附分子3结合非整合素（DC-SIGN）与埃博拉病毒（EBOV）包膜之间的相互作用。BH30sucMan在纳摩尔浓度下可抑制DC-SIGN介导的EBOV感染。BH30sucMan可能会抵消EBOV感染过程中的重要步骤，并且可能会抵消那些利用DC-SIGN进入细胞并进行感染的微生物感染过程中的重要步骤。
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