Pulst S-M
Division of Neurology, Cedars-Sinai Medical Center, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
J Neurol Neurosurg Psychiatry. 2003 Dec;74(12):1608-14. doi: 10.1136/jnnp.74.12.1608.
The advent of molecular biology has changed the way in which neurological illnesses are classified, and the single genes causing a number of disorders have been identified. In addition, techniques such as linkage analysis and DNA sequencing have resulted in greater understanding of multi-gene diseases. This review covers some of the molecular tools and animal models used for genetic analysis and for DNA based diagnosis, and a brief survey of information available on the internet.
分子生物学的出现改变了神经疾病的分类方式，并且已经确定了导致多种疾病的单个基因。此外，连锁分析和DNA测序等技术使人们对多基因疾病有了更深入的了解。本综述涵盖了一些用于遗传分析和基于DNA诊断的分子工具及动物模型，并简要介绍了互联网上可得的信息。
