[模拟氨茶碱从半固体基质中释放的动力学：聚乙二醇脂肪酸酯]
[Modeling the kinetics of theophylline release from a semi-solid matrix: Gelucire].
作者信息
Ortigosa Cl, Lasserre Y J
机构信息
Laboratoire de pharmacie galénique, pharmacotechnie et biopharmacie, faculté de pharmacie BP 14491, 15, avenue Charles Flahault, F 34093 Montpellier Cedex 5.
出版信息
Ann Pharm Fr. 2003 Nov;61(6):392-8.
Controlling release of a trace is an indispensable pharmacological technique. Release of the active substance can be modulated to meet the desired kinetic requirements of the formulation by carefully choosing the excipient and controlling the solubility of the tracer. We studied the preformulation of a semi-solid matrix, Gelucire, to examine the kinetic properties of theophylline release. Several models were analyzed. The results show that the formulation must be specific for the semi-solid matrix used.
控制微量物质的释放是一项不可或缺的药理学技术。通过仔细选择辅料并控制示踪剂的溶解度，可以调节活性物质的释放，以满足制剂所需的动力学要求。我们研究了半固体基质Gelucire的处方前研究，以考察茶碱释放的动力学性质。分析了几种模型。结果表明，制剂必须针对所使用的半固体基质具有特异性。
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