[Kinetics of liberation of the theophylline in semi-solid matrix based of Gelucire].
作者信息
Ortigosa Cl A, Lasserre Y J
机构信息
Laboratoire de pharmacie galénique, pharmacotechnie et biopharmacie, Faculté de pharmacie, B.P. 14491, 15, avenue Charles Flahault, F34093 Montpellier Cedex 5.
出版信息
Ann Pharm Fr. 2004 Mar;62(2):128-32. doi: 10.1016/s0003-4509(04)94291-5.
Abstract
Dissolution of a tracer included in Gelucire is primarily governed by two physico-chemical nominative parameters of this auxiliary substance which are its melting point and its hydrophily-lypophily balance. As they are not dissociable and their interaction is very significant, the optimisation of a formulation containing a mix of Gelucire cannot be done with polynomial models. An indirect modelisation, as Simplex, is however possible.
摘要
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