Pasquier Y, Cahana A, Schnider A
Spinal Cord Unit, Clinic of Reeducation, Department of Clinical Neuroscience, University Hospital of Geneva, Switzerland.
Spinal Cord. 2003 Dec;41(12):700-2. doi: 10.1038/sj.sc.3101536.
To report an unusual cause of intrathecal drug delivery failure in baclofen pump device.
A case report of an SCI patient treated with intrathecal baclofen, presenting a drug withdrawal.
Regional spinal cord injuries centre in Geneva (Switzerland).
We present a case of a 38-year-old male with complete T9 spastic paraplegia for 15 years, treated with intrathecal baclofen for 11 years. He recently presented to our centre with a spastic hypertonic episode, associated with rhabdomyolysis.
Standard investigations were unrevealing. However, a CT scan performed after injecting a radio-opaque solution by the side port of the pump, showed an unexpected catheter migration into the subdural space. Surgical revision reversed withdrawal symptoms.
Subdural catheter migration must be considered in the differential diagnosis of intrathecal drug delivery system failures. We recommend the use of the CT scan after contrast injection, to detect the localization of the distal catheter tip and confirm the normal diffusion into the subarachnoid space.
报告巴氯芬泵装置鞘内给药失败的一种罕见原因。
一名接受鞘内巴氯芬治疗的脊髓损伤(SCI)患者出现药物戒断的病例报告。
瑞士日内瓦的地区脊髓损伤中心。
我们报告一例38岁男性,T9完全性痉挛性截瘫15年,接受鞘内巴氯芬治疗11年。他最近因痉挛性高张力发作并伴有横纹肌溶解症前来我们中心就诊。
标准检查未发现异常。然而,通过泵的侧端口注入不透射线溶液后进行的CT扫描显示,导管意外迁移至硬膜下间隙。手术修复逆转了戒断症状。
硬膜下导管迁移必须纳入鞘内给药系统故障的鉴别诊断中。我们建议在注入造影剂后进行CT扫描,以检测导管远端尖端的位置并确认造影剂正常扩散至蛛网膜下腔。