Szabó J, Nosztray K, Csáky L, Szegi J
Acta Physiol Acad Sci Hung. 1976;48(1):79-86.
The effect of the beta-blocking agents propranolol and oxprenolol on isoproterenol-induced cardiac hypertrophy has been investigated in the rat. To evaluate the degree of inhibition biochemical parameters related to cardiomegaly were measured. When given alone in the dose range used for protection, the beta-blocking agents did not cause any significant change in total myocardial RNA, DNA and protein. Depending on the dose applied, propranolol and oxprenolol prevented partially or totally the cardiomegaly induced by isoproterenol.
在大鼠中研究了β受体阻滞剂普萘洛尔和氧烯洛尔对异丙肾上腺素诱导的心脏肥大的影响。为评估抑制程度，测量了与心脏肥大相关的生化参数。当在用于保护的剂量范围内单独给药时，β受体阻滞剂不会使总心肌RNA、DNA和蛋白质发生任何显著变化。根据所应用的剂量，普萘洛尔和氧烯洛尔可部分或完全预防异丙肾上腺素诱导的心脏肥大。
