Mercuri Eugenio, Barnett Anna L
Department of Paediatrics, Imperial College, Hammersmith Campus, London, United Kingdom.
Neural Plast. 2003;10(1-2):51-7. doi: 10.1155/NP.2003.51.
The aim of this paper is to review (i) the spectrum of neuromotor function at school age in children who had been born full-term and presented with neonatal encephalopathy (NE) and low Apgar scores and (ii) the relation between the presence/absence of such difficulties and neonatal brain MRI. Motor outcome appears to be mainly related to the severity of basal ganglia and internal capsule involvement. Severe basal ganglia lesions were always associated with the most severe outcome, microcephaly, tetraplegia, and severe global delay, whereas more discrete basal ganglia lesions were associated with athetoid cerebral palsy, with normal cognitive development, or minor neuro-motor abnormalities. White matter lesions were associated with abnormal motor outcome only if the internal capsule was involved. Children with moderate white matter changes but normal internal capsule had normal motor outcome at school age.
（i）足月出生且患有新生儿脑病（NE）和低阿氏评分的儿童在学龄期的神经运动功能谱；（ii）这些困难的有无与新生儿脑MRI之间的关系。运动结局似乎主要与基底神经节和内囊受累的严重程度有关。严重的基底神经节病变总是与最严重的结局、小头畸形、四肢瘫痪和严重的全面发育迟缓相关，而更离散的基底神经节病变与手足徐动型脑瘫、正常认知发育或轻微的神经运动异常相关。只有在内囊受累时，白质病变才与异常运动结局相关。白质有中度改变但内囊正常的儿童在学龄期运动结局正常。
