Kang Ok-Hap, Jahn Peter, Eichhorn Joachim G, Dresbach Till, Müller Andreas, Sabir Hemmen
Children's Hospital, Klinikum Leverkusen, 51375 Leverkusen, Germany.
Department of Neonatology and Pediatric Intensive Care, Children's Hospital University of Bonn, 53127 Bonn, Germany.
Children (Basel). 2023 Jul 27;10(8):1295. doi: 10.3390/children10081295.
(1) Background: Cerebral MRI plays a significant role in assessing the extent of brain injury in neonates with neonatal encephalopathy after perinatal asphyxia. Over the last decades, several MRI scoring systems were developed to enhance the predictive accuracy of MRI. The aim of this study was to validate the correlation of four established MRI scoring systems with cognitive long-term outcomes in cooled asphyxiated newborns. (2) Methods: Forty neonates with neonatal encephalopathy treated with therapeutic hypothermia were included in this retrospective study. The MRI scans from the second week of life were scored using four existing MRI scoring systems (Barkovich, NICHD, Rutherford, and Weeke). The patients' outcome was assessed with the Bayley Scales of Infant Development (BSID-III) at the age of 2 years. To evaluate the correlation between the MRI scoring system with the cognitive scores of BSID-III, the correlation coefficient was calculated for each scoring system. (3) Results: All four MRI scoring systems showed a significant correlation with the cognitive scores of BSID-III. The strongest correlation was found between the Weeke Score (r = 0.43), followed by the Rutherford score (r = 0.39), the NICHD score (r = 0.22), and the Barkovich score (r = 0.17). (4) Conclusion: Our study confirms previously published results in an independent cohort and indicates that the Weeke and Rutherford scores have the strongest correlation with the cognitive score of BSID-III in cooled asphyxiated newborns.
(1) 背景：脑磁共振成像（MRI）在评估围产期窒息后新生儿脑病患儿的脑损伤程度方面发挥着重要作用。在过去几十年中，开发了几种MRI评分系统以提高MRI的预测准确性。本研究的目的是验证四种已建立的MRI评分系统与低温治疗的窒息新生儿认知长期预后的相关性。(2) 方法：本回顾性研究纳入了40例接受治疗性低温治疗的新生儿脑病患儿。使用四种现有的MRI评分系统（Barkovich、NICHD、Rutherford和Weeke）对出生后第二周的MRI扫描进行评分。在患儿2岁时，使用贝利婴幼儿发育量表（BSID-III）评估其预后。为了评估MRI评分系统与BSID-III认知评分之间的相关性，计算了每个评分系统的相关系数。(3) 结果：所有四种MRI评分系统均与BSID-III的认知评分显著相关。发现Weeke评分（r = 0.43）的相关性最强，其次是Rutherford评分（r = 0.39）、NICHD评分（r = 0.22）和Barkovich评分（r = 0.17）。(4) 结论：我们的研究在一个独立队列中证实了先前发表的结果，并表明Weeke和Rutherford评分与低温治疗的窒息新生儿的BSID-III认知评分相关性最强。
