Taylor Stephen, Sadiq S Tariq, Weller Ian, Kaye Steve, Workman Judith, Cane Patricia A, Bennett Julie, Copas Andrew J, Drake Susan M, Pillay Deenan
HPA Antiviral Susceptibility Reference Unit, Division of Immunity and Infection, University of Birmingham, UK.
Antivir Ther. 2003 Oct;8(5):479-83.
Sexually transmitted infections may enhance the sexual transmission of HIV-1. It is possible that loss of virological control in patients with such infections receiving antiretroviral therapy (ART) may even facilitate the transmission of drug-resistant HIV. We have recently demonstrated that in those on maximally suppressive ART this effect is reduced. We have examined the virus obtained from the blood plasma and seminal plasma of six HIV-1-infected men receiving poorly suppressive ART with acute urethritis for the presence of drug resistance-associated mutations. In four men with gonorrhoea the blood and seminal plasma HIV-1 had mutations conferring reduced susceptibility to one or more available drugs. In one of these men the viral load of drug-resistant virus in seminal plasma was 20-fold higher during gonorrhoea than following antibiotic treatment, with no change in blood plasma viral load. We conclude that in the presence of suboptimal ART, sexually transmitted infections may enhance the spread of drug-resistant HIV-1.
性传播感染可能会增强HIV-1的性传播。接受抗逆转录病毒疗法（ART）的此类感染患者若病毒学控制不佳，甚至可能促使耐药HIV的传播。我们最近证明，对于接受最大抑制性ART的患者，这种影响会减弱。我们检测了6名接受抑制效果不佳的ART且患有急性尿道炎的HIV-1感染男性的血浆和精液血浆中的病毒，以寻找与耐药相关的突变。在4名患有淋病的男性中，血液和精液血浆中的HIV-1发生了突变，使其对一种或多种现有药物的敏感性降低。在其中一名男性中，淋病期间精液血浆中耐药病毒的病毒载量比抗生素治疗后高20倍，而血浆病毒载量没有变化。我们得出结论，在ART效果欠佳的情况下，性传播感染可能会增强耐药HIV-1的传播。
