Villar David, Carson Thomas L, Osweiler Gary, Bryan Roger
Veterinary Diagnostic Laboratory, Iowa State University, Ames, IA 50011, USA.
Vet Hum Toxicol. 2003 Dec;45(6):311-2.
Methionine tablets are used as urinary acidifiers for pets and to decrease damage from dog urine to lawns. A 39-kg Labrador Retriever ingested approximately 350 tablets containing 150 mg methionine/tablet and was presented after repeated episodes of vomiting. The only abnormality was posterior ataxia suggestive of spinal cord injury. The animal was treated with i.v. fluids, steroids and gastrointestinal protectants. Approximately 4.5 h after entering the clinic the dog had a single seizure episode lasting 2-3 min which was treated with phenobarbital. Serum ammonia at that time was normal (0.19 mg/dL). The animal did not show further CNS abnormalities and awoke apparently normal. A musty odor to the breath was noticed through the course of the day, possibly due to volatile mercaptans produced from methionine metabolism. The animal made an uneventful recovery and was discharged the next day.
蛋氨酸片用作宠物的尿酸化剂，并减少狗尿对草坪的损害。一只39公斤重的拉布拉多猎犬摄入了大约350片每片含150毫克蛋氨酸的药片，在反复呕吐后就诊。唯一的异常是提示脊髓损伤的后躯共济失调。该动物接受了静脉输液、类固醇和胃肠道保护剂治疗。进入诊所约4.5小时后，这只狗发生了一次持续2至3分钟的癫痫发作，用苯巴比妥进行了治疗。当时血清氨正常（0.19毫克/分升）。该动物未表现出进一步的中枢神经系统异常，醒来时明显正常。在一天中都能闻到一股霉味，可能是由于蛋氨酸代谢产生的挥发性硫醇所致。该动物顺利康复，第二天出院。
