Gaudy J H, Sicard J F, Gateau O, Maneglia R, Quignon M
Laboratoire d'Anesthésiologie, Faculté de Médecine Saint-Antoine, Paris, France.
Can J Anaesth. 1992 Dec;39(10):1094-8. doi: 10.1007/BF03008380.
Changes in systemic haemodynamic variables (mean arterial pressure, MAP; heart rate, HR; cardiac output, Qc), in oxygen consumption, VO2, and in ventilation (minute ventilation, V; respiratory frequency, f; tidal volume, VT; and arterial blood gases) with particular attention to respiratory times (duration of inspiration, TI; duration of expiration, TE; duration of the breathing cycle, TTOT), to respiratory timing (TI/TTOT) and respiratory drive (VT/TI) were studied during moderate progressive hypothermia (36 degrees C to 28 degrees C) during stable halothane anaesthesia (MAC = 1.5) in six dogs. MAP, HR and Qc decreased; V and f decreased, the decrease in f being correlated with that in temperature (r = 0.66; P < 0.01). Tidal volume did not change. The PaO2 and pHa decreased while PaCO2 increased slightly. The decrease in ventilation was related to changes in respiratory times (TI and TE) which increased (TE more than TI) and in respiratory drive (VT/TI which decreased due to the increase in TI). The relation between VT/TI and TI/TTOT changes was not constant during cooling. Changes in respiratory times and drive could be due to the effect of cold on medullar respiratory control.
研究了六只狗在稳定的氟烷麻醉（MAC = 1.5）下进行中度渐进性低温（36℃至28℃）期间全身血流动力学变量（平均动脉压，MAP；心率，HR；心输出量，Qc）、氧耗量（VO2）和通气（分钟通气量，V；呼吸频率，f；潮气量，VT；以及动脉血气）的变化，特别关注呼吸时间（吸气持续时间，TI；呼气持续时间，TE；呼吸周期持续时间，TTOT）、呼吸定时（TI/TTOT）和呼吸驱动（VT/TI）。MAP、HR和Qc下降；V和f下降，f的下降与温度下降相关（r = 0.66；P < 0.01）。潮气量未改变。动脉血氧分压（PaO2）和动脉血pH值（pHa）下降，而动脉血二氧化碳分压（PaCO2）略有升高。通气量的下降与呼吸时间（TI和TE）的变化有关，呼吸时间增加（TE增加幅度大于TI），以及呼吸驱动（VT/TI因TI增加而下降）。在降温过程中，VT/TI与TI/TTOT变化之间的关系并不恒定。呼吸时间和驱动的变化可能是由于寒冷对延髓呼吸控制的影响。
