Xu Jinping, Sobel Jack D.
101 East Alexandrine, 2nd floor, Detroit, MI 48201, USA.
Curr Infect Dis Rep. 2003 Dec;5(6):481-487. doi: 10.1007/s11908-003-0091-x.
Vulvovaginal candidiasis (VVC) is one of the most common causes of vaginitis, and its incidence has increased markedly during the past three decades. The widespread overuse of antibiotics has been suggested as one of the major factors contributing to the increasing incidence of VVC. However, evidence supporting this association has been limited because few studies with rigorous scientific methodology have been conducted. Moreover, existing data regarding the risk for developing VVC after antibiotic use are conflicting. This review examines the available information in the literature regarding antibiotic-associated VVC, its incidence, and its potential mechanisms. Implications for clinical practice and research are also discussed.
外阴阴道念珠菌病(VVC)是阴道炎最常见的病因之一,在过去三十年中其发病率显著上升。抗生素的广泛过度使用被认为是导致VVC发病率上升的主要因素之一。然而,支持这种关联的证据有限,因为很少有采用严格科学方法的研究。此外,关于使用抗生素后发生VVC风险的现有数据相互矛盾。本综述考察了文献中关于抗生素相关VVC、其发病率及其潜在机制的现有信息。还讨论了对临床实践和研究的启示。