可卡因暴露后胎羊发生癫痫发作：一例报告。

Seizures in a fetal lamb after cocaine exposure: a case report.

作者信息

Peters A J, Abrams R M, Burchfield D J, Gilmore R L

机构信息

Department of Obstetrics and Gynecology, University of Florida College of Medicine, Gainesville 32610-0294.

出版信息

Epilepsia. 1992 Nov-Dec;33(6):1001-4. doi: 10.1111/j.1528-1157.1992.tb01750.x.

DOI:10.1111/j.1528-1157.1992.tb01750.x

PMID:1464255

Abstract

We report the chance observation of two generalized seizures in a fetal lamb that received cocaine. Cocaine was infused intravenously into a 138-day-old fetus while electrocortical (ECoG), electroocular (EOG), and neck electromyographic (EMG) activity were recorded. Fetal rapid eye movement (REM) and nonrapid eye movement (NREM) sleep were disrupted during the cocaine exposure and returned to a normal pattern after infusions were stopped. Seventy-two hours later, however, we recorded generalized seizures with ECoG spike and spike wave activity.

摘要

我们报告了在一只接受可卡因的胎羊中偶然观察到的两次全身性癫痫发作。在记录皮质电图（ECoG）、眼电图（EOG）和颈部肌电图（EMG）活动时，将可卡因静脉注射到一只138日龄的胎儿体内。在可卡因暴露期间，胎儿快速眼动（REM）和非快速眼动（NREM）睡眠受到干扰，在停止输注后恢复到正常模式。然而，72小时后，我们记录到伴有ECoG棘波和棘慢波活动的全身性癫痫发作。