Yamamoto Tatsuo, Saito Osamu, Shono Koyo, Hirasawa Serabi
Department of Anesthesiology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo, Chiba-shi, Chiba 260-8670, Japan.
Eur J Pharmacol. 2003 Nov 28;481(2-3):175-80. doi: 10.1016/j.ejphar.2003.09.022.
Orexin-A and orexin-1 receptors are found in the dorsal root ganglion cells and the spinal dorsal horn and this suggests that orexin-A is involved in the spinal nociceptive transmission. The authors examined the effect of intrathecally administered orexin-A on the level of mechanical allodynia and thermal hyperalgesia induced by paw carrageenan injection in the rat. Intrathecal injection of 0.3 and 3 nmol of orexin-A suppressed the level of mechanical allodynia, but not that of thermal hyperalgesia, and the effect of orexin-A on mechanical allodynia was antagonized by the pretreatment of 1-(2-methylbenzoxazol-6-yl)-3-[1,5]naphthyridin-4-yl urea hydrochloride, SB-334867, a selective orexin-1 receptor antagonist. These data suggest that the activation of spinal orexin-1 receptor modulates the mechanical information transmission, but not thermal information transmission, in the spinal cord during carrageenan test.
在背根神经节细胞和脊髓背角中发现了食欲素-A和食欲素-1受体，这表明食欲素-A参与脊髓伤害性感受传递。作者研究了鞘内注射食欲素-A对大鼠爪部注射角叉菜胶诱导的机械性异常性疼痛和热痛觉过敏水平的影响。鞘内注射0.3和3 nmol的食欲素-A可抑制机械性异常性疼痛水平，但对热痛觉过敏水平无抑制作用，且1-(2-甲基苯并恶唑-6-基)-3-[1,5]萘啶-4-基脲盐酸盐（SB-334867，一种选择性食欲素-1受体拮抗剂）预处理可拮抗食欲素-A对机械性异常性疼痛的作用。这些数据表明，在角叉菜胶试验期间，脊髓食欲素-1受体的激活调节脊髓中的机械信息传递，但不调节热信息传递。
